DMA REPLICATION

Replicationcomplex (Prokaryotes) 5 '

lagging strand

r

DMA ligase

RNase H / poi I

Remoral of RN A primer Gap-filling

Joining of Okazaki fragment

DNA polymerase III holoenzyme

poi III core

leading strand

5 ' 3 '

poi III core

DNA polymerase III holoenzyme

pnmase

3 ' 5 '

V 6 complex

DKApofrmeneel DNA. Łgćce

Replicationcomplex (Eukaryotes)

lagging strand

5 '

3 '

Joining of Okazaki fragment

RNase HI or Dna2

Removal of RN A primer Gap-filling

DNApolymerase 6

EN W    complex

leading strand

5 ' 3 '

clamp

clamp loader

DNA polymerase a- primese complex

RPA

DNApolymerase e complex

3 ' 5 '

MCM complex (helicase)

RPA1

RPA2M

RPA3

clamp

clamp loader

03030 04/16/03

Fenl

DMAłigeee

Ligi