F00574 004 f006
Failure of thymic development: DiGeorge syndrome
Failure of expressiorn of HLA molecules: L Barę lympbocyte syndromes
0<)
Lymphoid progenitors
s
Failure of lymphocyte precursors:
Severe combined immune deficiency
• Thymus
Proliferation and maturation of thymocytes
Export of maturę T lymphocytes to periphery
Stern
cells
Bonę
marrow
Failure of normal cytokine production: Cytokine deficiencies
Failure of normal apoptosis: Autoimmune lymphoproliferative syndromes
T-lymphocyte activation and effector function
Apoptotic celi death
© Elsevier. Boon et al.: Davidson's Principles and Practice of Mediclne 20e - www.studentconsult.com
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