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Stagc

Steps in rcplication

Drug targcts

1

Attachment to CD4 receptor

2

Binding to co-receptor CCR5 or CXCR4

CCR5/CXCR4 receptor inhibitors

3

Fusion

Fusion inhibitors

4

Reverse transcription

Nucleoside and non-nucleoside reverse transcription inhibitors

5

Integration

Integrase inhibitors

6

Transcription

7

Translation

8

Cleavage of polypeptides and assembly

Protease inhibitors

9

Viral release