4

4



Regulacja syntezy i degradacji glikogenu

Ser14 OH side |

(Glucose)„ + Pj-► (glucose)*-! + glucose 1-phosphate


OH Ser14 side

CH., chain

/ *


Glycogen


Shoi*tened

glycogen

chain


Phosphorylase a + 2H20-► phosphorylase b + 2Pi P pKo«phatase


(morę active)


(less active)


(PPD


-1-

Phosphorylase b (less active)


2Pj 2ATP


2H20 2ADP


mięśnie stan spoczynku


<er


glucagon

^'(liver)


A

/


phosphorylase b kinase


®L cpincphrinc.

"'•tlCa2’|,tlAMPl (muacle)


2ATP + phosphorylase b (less active)


2ADP + phosphorylase a (morę active)


-7—

Phosphorylase a (active)

_L_


ch2


©


o


FIGURĘ 15-24 Regulation of muscle glycogen phosphorylase by covalent modification. In the morę active form of the enzyme, phosphorylase a, Ser14 residues, one on each subunit, are phosphorylated. Phosphorylase a is converted lo the less active form, phosphorylase b, by enzymatic loss of these phosphoryl groups, catalyzed by phosphorylase a phosphatase (PP1). Phosphorylase b can be reconverted (reactivated) to phosphorylase a by the action of phosphorylase b kinase.


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