NLs

Transport to the nucleus (NLS) -Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-

Transport to the endoplasmic reticulum H₂N-Met-Met-Ser-Phe-Val-Ser-Leu- Leu-Leu-Val-Gly-lle-Leu-Phe-Trp-Ala-Thr-Glu-Ala-Glu-GIn- Leu-Thr-Lys-Cys-Glu-Val-Phe- Gln-Retention to the endoplasmic reticulum -Lys-Asp-Glu-Leu-COOH

Transport to the mitochondrial matrix H₂N-Met-Leu-Ser-Leu-Arg-Gln-Ser- lle-Arg-Phe-Phe-Lys-Pro-Ala- Thr-

Arg-Thr-Le u-Cys-Se r-Se r- Arg-Tyr-Le u-Le u-

Transport to the peroxisome (PTS1) -Ser-Lys-Leu-COOH

Transoort to the oeroxisome (PTS2) H.N-----Are-Leu-X.-His-Leu-    ____

Humań influenza    4

virus A    Met Lys Ala Lys Lcu Lcu Val Lcu Leu 1Vr Ab Phc Val Ala Gly Asp Gb —

Humań    +

preproinsulin Met Ab Leu Trp Met Arg Leu Lcu Pro Lcu Lcu Ala Lcu Leu Ab Leu Trp Gly Pro Asp Pro Ala Ala Ab Phc Val —

Met Met Ala Ala Gly Pro Arg Tłu- Ser Leu Leu Leu Ab Phe Ab Leu Leu Cya Leu Pro Trp Hu- Gin Val Val Gly Ab Phe —

Drosophila glue    +

protein    Met Lys Lcu Leu Val Val Ab Val Ib Ab Cya Met Leu Ile Gly Phe Ab Asp Pro Ab Ser Gly Cya Lys —

FIGURĘ 27-37 Amino-terminal signal sequences of some eukaryotic    the polar and short-side-chain residues immediately preceding (to the

proteins that direct their translocation into the ER. The hydrophobic    left of, as shown here) the cleavage sites (indicated by red arrows).

core (yellow) is preceded by one or morę basie residues (bluej. Notę

Sekwencje sygnałowe mają długość od 13 do 36 reszt aminokwasowych, o następujących cechach:

(1)    około 10 do 15 hydrofobowych aminokwasów,

(2)    jedną lub więcej dodatnio naładowanych reszt, zazwyczaj w pobliżu N-końca, poprzedzającą hydrofobową sekwencję, oraz

(3)    krótka sekwencja na końcu karboksylowym (w pobliżu miejsca cięcia), która jest stosunkowo polarna, mająca zwykle reszty aminokwasowe o krótkich łańcuchach bocznych (zwłaszcza Ala) w pozycjach najbliższych do miejsca cięcia.

Wyszukiwarka

Podobne podstrony:
DSC103 Piasn a meml r<Fic w of membranes ancl other materials from the emłoplasmic reticulum thro
Photo Pro Magazine November 10 THE UK S FASTEST GROWING PROFESSIONAL PHOTOGRAPHY MAGAZINETaking yo
WK* Guitar Pro needs to be activated upon first use. BK/ Please enter the license information (USER
26 PRO)ECT FIVE • 8EA0E0 AMULET PURSES Be surę to puli the warp threads close to the woven beads as
Please go to the Guitar Pro website, SUPPORT section, choose Offline Actiyation," and type in
80054 image044 (14) V Safe To Remove Hardware The NDPA-02 DDCS/PC Gard’ device can now be safely re
synare4 bmp NOISE GENERATOR. this Circuit. (Don t forget to tap the speaker to turn the power on.) M
CameraZOOM 20130510083748235 Name (»ro u p I >n tc I. I sc unothcr form of the word on the r
mbs 007 THE AUTHOR S PREFACE TO THE THIRI) EDITION Since the first edition was published, I liave ha
19 Marcin Łączek exams, of course, marked by independent exam boards) and are automatically pro-mote
Running the Setup Program The first part of the Setup program is text~based, not a wizard. To run th
The President then passed on to Section 11, Art. 4, and pro-posed to rcplace the second paragraph of
A NetWork of Mining and Metallurgy The EU pro

więcej podobnych podstron