47750 netter160

47750 netter160



GASTROINTESTINAL PHYSIOLOGY

Absorption of Essential Elements and Vitamins


Iron



Element

Site of Absorption

Mcchanism

Ca2*

Duodenum and jejunurn

Active

Fe2*

Duodenum and jejunum

Facilitated diffusion

Water-Soluble Vitamins

Vitamin C

lleum

Na*-coupled/2° acłive

Thiamin (Bj)

lejunum

Na*-C0upled/2° active

Ribotlavin (B2)

Jejunum

Na~-coupled/2“ active

Biotin

Jejunum

Na*-coupled/2° active

Vitamin B12

lleum

Facilitated diffusion

Pyridoxine (Bb)

Jejunum and ileum

Passive diffusion

Fat-Soluble Vitamins

Vitamin A

Jejunum and ileum

Passive diffusion

Vitamin D

Jejunum and ileum

Passive diffusion

Vitamin E

Jejunum and ileum

Passive diffusion

Vitamin K

Jejunum and ileum

Passive diffusion


Fal-Soluble Vitamins J. Perkins


Figurę 7.38 Absorption of Essential Vitamins and Elements .

The celi mechanisms involved in the absorption of Ca", iron, and several imporiant vitamins are summarized. Vitamin D, (1,25-dihy-droxy-vitamin D,) plays an imporiant role in stimulating inteslinal Ca ‘ absorption. Intrinsic tactor is madę by the stornach (see Figuro 7.12). If insufficient amounts of intrinsic tactor are produced, B,.. deficiency ensues. Failure to property digest fats (see Figurę 7.37) can lead to deficiencies of the fat-solu-ble vitamins. Abbreviations: DMTI, Divalenl metal transporter 1: FR. tuirireductase; H. hephaestin; IF, intrinsic factoi: IREC1, iron-regulated transporter 1; TCII, transcobalamin II; TF, transferom

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