IMG 59 (4)
How different are gastro-intestinal and respiratory mucosal immune systems?
TdMe 1. Comparisons of secondary lymphoid organs
|
Feature |
NALT |
PP |
BAL |
1 s |
|
Follicle-assodated epithelium |
■f |
+ |
: | |
|
M cells |
•f |
+ |
+ |
_ |
|
Intra-epithelal l/mphocytes |
♦ |
+ |
+ |
- |
|
Genminal centers |
♦ |
+ |
+ |
+ |
|
Dendritic cels |
+ |
+ |
+ |
+ |
|
Macrophages |
+ |
♦ |
+ |
+ |
|
HEV-PNAd |
+ |
+ |
+ |
- |
|
MAdCAM-l |
+ |
+ |
» |
“ |
|
T: B-cell ratio |
09 |
0.2 |
0-7 |
u |
|
CD4: CD®4 ratio |
-14- |
Ł0- |
BAŁT, bronchus-associated lymphoid tissue; NALT, nasal-associated lymphoid tissue.
1. Immunization via orał route results in induction of predominantly mucosal antibodies
2. Immunization via intranasal route results in induction of serum and mucosal antibodies
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