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Genetics: Mutations 10% of all Ol cases are caused by recessive mutations in genes that regulate the post-translational modification/processing of type I collagen and genes that help modulate osteoblast (large celi responsible for the synthesis and mineralization of bonę) differentiation and bonę mineralization
• CRTAP gene: Encodes a cartilage associated protein -1 cartilage is an important flexible connective tissue that keeps joint motion fluid by coating the surfaces of the bones and cushioning them against impact
LEPRE1 gene: Involved in post-translational modifications to collagen
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