4265276286

Varable	Converters at 2 years	Non-converters at 2 years	p value
Age	78.3 ± 2.5	73,3 ± 0.4	<0.001
Education (in years)	8.8 ±4.2	9.0 ±3.9	NS
MMSE	27.4 ± 0.9	27.8 ± 0.9	NS
ADAS-cog	13,1 ± 1.7	11,5 ±2,1	<0,001
Amnestic/Multiple domain subtype of MCI	6/27	33/23	<0,01
Gender (M/F)	5/22	20/36	NS
Depression	6/21	5/51	NS
Anxiety	5/22	6/50	NS
Apathy	18/9	2/54	<0,001
Mood lability	2/25	8/44	NS

Raw relative risk of developing dementia within 2 years for patinets who were apathetic at baseline versus those without apathy was 18,6 (95% Cl 5,8 -r 69,0). After controlling for possible confounders such as age, MCI subtype and baseline ADAS-cog, RR for apathetic subjects remained significant and reached 9,2 (95% Cl 2,9    28,5). Apathy also remained in a

multivariate backward stepwise logistic regression model for conversion after 24 months of observation.

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